Patient Care | Mood Disorders Research Program | Department of Psychiatry and Behavioral Sciences

Deep Brain Stimulation (DBS) is a treatment being studied for people with treatment-resistant depression—when someone hasn’t found relief after trying at least four different antidepressants. DBS involves a surgery where small electrodes are placed in the brain to gently stimulate areas that may help improve mood and reduce depression symptoms.

Cariprazine is a medication used to treat mood episodes in Bipolar I Disorder, including both mania and depression. In this study, we’re looking at how well it works in daily life—how helpful it is, how well people tolerate it, and how it affects overall quality of life.

This study is currently closed to new participants.

Transcranial Magnetic Stimulation (TMS) is a noninvasive treatment that can help when depression isn’t getting better with medication. It uses magnetic pulses to activate specific areas of the brain. With repeated sessions, TMS can help restore healthy brain activity and relieve symptoms—often with fewer side effects than medication.

TMS is currently approved for treatment of Major Depressive Disorder for adults age 18 and older whose depression symptoms have not responded to medications.

Esketamine (brand name Spravato®) is a U.S. Food and Drug Administration (FDA) approved antidepressant medication that is administered as a nasal spray. Esketamine is used to treat adults age 18 or older with Major Depressive Disorder who have not responded to two or more antidepressant medications, or who are experiencing suicidal thoughts. This medication can be used in combination with an oral antidepressant medication.