Animal Models
Our studies focus on utilizing nonhuman primate models in neurodevelopmental and behavioral research.
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California National Primate Research Center
Autism Phenome Project LabDescription
The California National Primate Research Center (CNPRC) at UC Davis is one of seven primate research centers supported by the National Institutes of Health. Collectively, the national primate research centers are a unique resource for investigators studying human health and disease, offering the opportunity to study potential cures, treatments, and preventive measures in nonhuman primate models that most closely resemble human responses. Research performed at the CNPRC provides necessary information before proceeding to clinical trials in humans and has led to new drugs and therapies that benefit human health and quality of life.Funding
National Institutes of Health / National Institute of Mental Health, Office of the Director
David G. Amaral, Ph.D.
Core scientist, Brain, Mind, and Behavior Research unit
dgamaral@ucdavis.edu -
Genetically modified nonhuman primates for neurodevelopmental research
Autism Phenome Project LabDescription
To better understand the neurobiological and molecular underpinnings of autism spectrum disorder, a first goal of this application is to develop a nonhuman primate model through genetic modification of the CHD8 gene. This gene is among the most frequently mutated genes in individuals with autism spectrum disorder (ASD). A long-term goal is to establish infrastructure to enable the generation of genetically modified monkeys for translational biomedical research — which we believe to be in the national interest.Funding
National Institutes of HealthDavid G. Amaral, Ph.D.
Principal Investigator
dgamaral@ucdavis.edu