Services and equipment
Services and Equipment
- Hands-on user training to perform library synthesis and screening
- Pre-made one-bead one-compound (OBOC) and one-bead two-compound (OB2C) combinatorial libraries
- Design, synthesis and screening of custom-made combinatorial libraries
- Screening of the pre-made combinatorial libraries against targets provided by users
- Sequencing and structural determination of the positive hits from library screening
- Re-synthesis of compounds (peptides, peptidomimetics peptoids, PNA and small molecules) in on-bead and soluble form for in vitro and in vivo evaluation
- Telodendrimer-based nanomicelles for nanoformulation and in vivo delivery of hydrophobic drugs
- Polyvinyl alcohol (PVA)-based nanomicelles for loading or conjugation of drugs
- Transformable peptide nanoplatform
- Optimization of lead compounds
- Custom synthesis of compounds
- HPLC purification, analysis and quantification
- Full consultation service
Major equipment
- ABI protein microsequencer for the decoding of positive beads
- Fluorescent microscopes for library screening using fluorescent probes
- Stereo and confocal microscopes for routine library screening
- HPLC systems for the purification of the compounds synthesized by the Shared Resource
- Automated peptide synthesizer for synthesis of individual peptides on a large scale
- CEM microwave peptide synthesizer for rapid synthesis of long and difficult peptides