Dermatology Clinical Trials
Advancing Research and Care for a Variety of Skin Conditions
The UC Davis Health Department of Dermatology conducts a variety of clinical trials designed to evaluate promising new treatments and advance the field of dermatology. By participating, you may gain access to innovative therapies while contributing to research that has the potential to improve care for countless individuals.
Actively Enrolling Clinical Trials
Explore the following conditions to learn more about research studies that might be right for you.
Efficacy and safety of cryotherapy versus 5-fluorouracil in the treatment of actinic keratosis: a prospective, randomized controlled, intra-individual trial
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- A clinical diagnosis of 10 or more actinic keratosis patches on the head, neck or extremities
Enrollment: Ongoing until December 2025
Aesthetic outcome of tie-over bolster application in surgical wounds: a randomized evaluator-blinded split-wound comparative effectiveness trial
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Scheduled for cutaneous surgical procedure on the head or neck with predicted primary closure
- Willing to return for a follow-up visit
Enrollment: Ongoing until September 2025
Aesthetic outcome of intra-dermal versus transcutaneous purse-string closure: a randomized evaluator-blinded split-wound comparative effectiveness trial
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Scheduled for cutaneous surgical procedure on the head, neck, trunk or extremities with predicted purse-string closure
Enrollment: Ongoing until December 2027
A phase 3 randomized, placebo-controlled, double-blind program to evaluate efficacy and safety of upadacitinib in adult and adolescent subjects with severe alopecia areata
Primary Investigator: Emmanuel Mavrakis, M.D.
Contact: Lauren Downing, ladowning@health.ucdavis.edu
Participant Criteria:
- Individuals ages 12-64 at baseline
- Diagnosis of severe alopecia areata with severity of alopecia tool (SALT) score of at least 50 scalp hair loss at screening and baseline
- Severe alopecia areata with no spontaneous scalp hair regrowth over the past 6 months
- Current episode of alopecia areata of less than 8 years
Enrollment: Adult enrollment is closed. Adolescent enrollment is expected to close by the end of 2025.
Pilot study on intralesional cyclosporine for alopecia areata
Primary Investigator: Oma Agbai, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- Aged 18-65 at screening visit
- Diagnosis of alopecia areata by a board-certified dermatologist at screening visit
- Current alopecia areata episode that involves the scalp of more than 3 months' duration (prior to baseline visit)
- SALT score between 10 and 50 at baseline visit
- Agree not to use any alopecia areata treatments during the study
Enrollment: Ongoing until December 2026
A study to learn about medicine called ritlecitinib in children aged between 6 to 12 years with severe alopecia areata
Primary Investigator: Emmanuel Mavrakis, M.D.
Contact: Jordan Nava, jonava@health.ucdavis.edu
Participant Criteria:
- Ages 6-12
- A diagnosis of alopecia areata with at least 50% scalp hair loss due to alopecia areata (i.e., SALT score of 50 or greater) at both screening and baseline visits, without evidence of terminal hair regrowth within the previous 12 months
Enrollment: Ongoing until January 2027
USCLC National Cutaneous Lymphoma Registry
Primary Investigator: Peggy Wu, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- All ages
- Patients living with cutaneous lymphoma
Enrollment: Ongoing
A multicenter, randomized, double-blind, placebo-controlled study to evaluate efficacy, pharmacokinetics, and safety of repeat subcutaneous doses of FB825 in adults with moderate-to-severe atopic dermatitis
Primary Investigator: Victor Huang, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- Ages 18-65
- Diagnosis of moderate-to-severe atopic dermatitis
- Eczema Area and Severity Index (EASI) score greater than or equal to 16
- Greater than 10% body surface area
- History of inadequate response to a stable (i.e., 4-week) regimen of topical corticosteroids (TCI) or topical calcineurin inhibitors (TCS) as treatment for atopic dermatitis within 6 months before the screening visit
Enrollment: Ongoing until March 2026
A phase 3, multi-center trial to evaluate the efficacy and safety of tralokinumab in combination with topical corticosteroids in children (age 2 to <12 years) and infants (age 6 months to <2 years) with moderate-to-severe atopic dermatitis
Primary Investigator: Smita Awasthi, M.D.
Contact: Jordan Nava, jonava@health.ucdavis.edu
Participant Criteria:
- Pediatric patient ages 6 months to less than 12 years old at screening
- An EASI score of greater than or equal to 16 at screening and baseline
- Atopic dermatitis involvement of greater than or equal to 10% body surface area at screening and baseline
- Diagnosis of atopic dermatitis as defined by the Hanifin and Rajka criteria
Enrollment: Ongoing until June 2026
Dermatitis quality of life assessment pre- and post-patch testing questionnaire
Primary Investigator: Peggy Wu, M.D.
Contact: Jasmin Johl, jesjohl@health.ucdavis.edu
Participant Criteria:
- Patients referred to UC Davis Health Department of Dermatology for evaluation of rash or dermatitis
Enrollment: Ongoing
A systematic assessment of patch testing outcomes
Primary Investigator: Peggy Wu, M.D.
Contact: Jasmin Johl, jesjohl@health.ucdavis.edu
Participant Criteria:
- Patients referred to UC Davis Health Department of Dermatology for evaluation of rash or dermatitis
- All ages, including those younger than 18 with parental consent
Enrollment: Ongoing
Genetic aberrations driving cutaneous disease
Primary Investigator: Maija Kiuru, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- Subjects with an active cutaneous, hair or nail disease confirmed by a dermatologist
- 18 years of age or older
- Younger than age 18 with informed consent provided by legal guardian. Only buccal swab for DNA isolation will be performed.
Enrollment: Ongoing
A Phase 3 randomized, placebo-controlled, double-blind study to evaluate efficacy and safety of upadacitinib in adult and adolescent subjects with moderate-to-severe hidradenitis suppurativa who have failed anti-TNF therapy
Primary Investigator: Emmanuel Mavrakis, M.D.
Contact: Lauren Downing, ladowning@health.ucdavis.edu
Participant Criteria:
- Individuals ages 12 and older with moderate-to-severe hidradenitis suppurativa
- Documented history of previous use of greater than or equal to 1 tumor necrosis factor (TNF) inhibitor for hidradenitis suppurativa for at least 12 weeks and/or 1 approved non-anti-TNF biologic therapy for hidradenitis suppurativa for at least 16 weeks characterized by inadequate response or for any duration characterized by intolerance as determined by the investigator
- Participant must have a total abscess and inflammatory nodule (AN) count of greater than or equal to 5 at baseline
- Hidradenitis suppurativa lesions must be present in at least two distinct anatomic areas at baseline
Enrollment: Ongoing until December 2025
Ethyl chloride spray to reduce pain from local anesthesia during Mohs micrographic surgery
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Scheduled for Mohs micrographic surgery
- Pre-operative tumor size of at least 1.5 cm
Enrollment: Ongoing until December 2025
Undermining apices in surgical wounds: a randomized evaluator-blinded split-wound comparative effectiveness trial
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Scheduled for cutaneous surgical procedure on the neck, trunk and extremities with predicted primary closure
Enrollment: Ongoing until December 2026
Barbed versus traditional suture for repair of dermatologic surgery defects: a randomized evaluator-blinded split-wound comparative effectiveness trial
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Scheduled for cutaneous surgical procedure on the neck, trunk and extremities with predicted primary closure
- Able to give informed consent themselves
Enrollment: Ongoing until December 2027
Effect of pre-operative consultation on patient anxiety and satisfaction following first-time Mohs micrographic surgery
Primary Investigator: Daniel Eisen, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Fluent in English
- Presenting for first-time Mohs micrographic surgery for treatment of a cutaneous malignancy
Enrollment: Ongoing until December 2027
Genetic basis of melanocytic nevi
Primary Investigator: Maija Kiuru, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- Subjects with melanocytic nevi
- 18 years of age and older
- 5 years of age and older (individuals with RASopathy only)
Enrollment: Ongoing
A phase 1/2, open-label, safety and dosing study of autologous CAR T cells (desmoglein 3 chimeric autoantibody receptor T cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T cells [CABA-201]) in subjects with active, pemphigus vulgaris
Primary Investigator: Emmanuel Mavrakis, M.D.
Contact: Lauren Downing, ladowning@health.ucdavis.edu
Participant Criteria:
- Individuals ages 18 and older
- Confirmed diagnosis of mean platelet volume by prior or screening biopsy and prior positive anti-DSG3 antibody ELISA
- Mean platelet volume inadequately managed by at least one standard immunosuppressive therapy
- Active mean platelet volume at screening
- Anti-DSG3 antibody ELISA positive at screening; inclusion criteria for CABA-201 sub-study
- Pemphigus vulgaris inadequately managed by at least one standard immunosuppressive therapy
- Active pemphigus vulgaris at screening
- DSG3 ELISA positive at screening
Enrollment: Ongoing
Biomarker expression in an adhesive patch-based assay for pigmented lesions
Primary Investigator: Maija Kiuru, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Subject must have one of the following:
- At least one pigmented lesion that is greater than or equal to 4 mm in diameter
- A pigmented lesion that is confirmed to be melanoma to serve as a control
- An area of skin without a pigmented lesion to serve as a control
- If the subject has multiple pigmented lesions, the lesions must be at least 4 mm apart
Enrollment: Ongoing until December 2027
A study to determine the effect of a 6-week healthy nutrition intervention on qualitative and objective markers of inflammation in patients with psoriasis
Primary Investigator: Samuel Hwang, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- History of psoriasis of at least 3% body surface area
- A BMI of 25 or greater
- Recruited patients must habitually consume a Western-type diet
Enrollment: Ongoing until June 2026
A study to conduct ongoing investigations to elucidate the pathogenesis behind local and systemic inflammation in patients with psoriasis through blood and skin samples
Primary Investigator: Samuel Hwang, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- A diagnosis of psoriasis or atopic dermatitis as determined by a doctor OR a patient who is a health control who has not been diagnosed with psoriasis or atopic dermatitis
Enrollment: Ongoing
Clinical impact of sleep-targeting interventions in psoriasis patients
Primary Investigator: Victor Huang, M.D.
Contact: Morgan Danielle Murry, mdmurry@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Diagnosis of psoriasis as determined by a dermatologist
- Is untreated or receiving skin-directed therapy only (topicals or phototherapy)
- Has adhered to a stable psoriasis management plan for the past two months
- Has a Pittsburgh sleep quality index (PSQI) score of 5 or greater, which correlates with poor sleep
Enrollment: Ongoing until December 2027
A phase 3b/4 multi-center, randomized, open-label, long-term safety study of deucravacitinib in comparison to ustekinumab in participants with moderate-to-severe plaque psoriasis
Primary Investigator: Emmanuel Mavrakis, M.D.
Contact: Jordan Nava, jonava@health.ucdavis.edu
Participant Criteria:
- At least 40 years old
- Diagnosis of moderate-to-severe plaque psoriasis
- Have at least one of the following cardiovascular risk factors:
- Current cigarette smoker
- Diagnosis of hypertension
- Diagnosis of hyperlipidemia
- Diagnosis of diabetes Type 1 or 2
- Diagnosis of obesity
- Family history of premature coronary heart disease
- History of one or more cardiovascular events, including coronary intervention (PCI) or coronary artery bypass grafting (CABG), myocardial infarction (heart attack), cardiac arrest, hospitalization for unstable angina, acute coronary syndrome, stroke or transient ischemic attack
Enrollment: Ongoing until June 2026
A systematic assessment of vitiligo outcomes – a patient registry study
Primary Investigator: Victor Huang, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- Patients referred to UC Davis Health Department of Dermatology for vitiligo diagnosis and treatment
Enrollment: Ongoing
Analysis of sebaceous tumors derived from subjects with Muir-Torre syndrome or Lynch syndrome or hereditary non-polyposis colorectal cancer
Primary Investigator: Maija Kiuru, M.D.
Contact: Salsala Nasim, sanasim@health.ucdavis.edu
Participant Criteria:
- At least 18 years old
- Subjects with a sebaceous tumor and MSH2/MSH6/MLH1 deficiency identified with immunohistochemistry
- AND/OR
- Subjects with a sebaceous tumor and diagnosis of Muir-Torre syndrome or Lynch syndrome or hereditary non-polyposis colorectal cancer syndrome
Enrollment: Ongoing until December 2028
Express Interest in Clinical Trials
Interested in exploring our clinical trials in more detail? Visit our dedicated hub to browse active dermatology studies, check your eligibility and express your interest in participating.