Natural language processing of biomedical text to map and prioritize protein–disease associations in HFpEF
March 2026
Abstract
The validation of promising clinical biomarkers, molecular mechanisms, and novel drug targets in cardiovascular disease (CVD) is hindered by a vast and fragmented biomedical literature, which now exceeds 38 million publications indexed in PubMed. To address the central challenge of navigating and synthesizing a huge fragmented biomedical literature base, we applied our validated machine learning–based text-mining algorithm containing natural language processing (NLP) and incorporated this into a ValIdated Text-mining using Advanced Language model (VITAL) as a complementary framework.
2nd Worldwide Sodium Channel Conference 2026
February 2026 — Vladimir Yarov-Yarovoy attended the 2nd World Sodium Channel Conference in Grindelwald, Switzerland, and presented a recently published research project entitled “Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2”. This study demonstrates the power of deep learning–based structural methods to advance understanding of voltage-gated sodium channel gating and drug modulation, while emphasizing that computationally predicted states remain hypotheses requiring experimental validation.
Theranostics Digital Twins: A Path to Personalized Medicine
January 2026 — On January 14, the Data Science Seminar Series has tackled an intersection of two critical data science concepts in cancer research: theranostics and digital twins. Emilie Roncali, an associate profession at UC Davis, gave an overview of how these concepts work in practice in liver, prostate, and metastatic cancer.
GenScript Life Science Research Grant (LSRG) for AI Drug Discover Project
January 2026 — Vladimir Yarov-Yarovoy received the GenScript Life Science Research Grant (LSRG) for AI Drug Discover project. Yarov-Yarovoy’s project focuses on targeting voltage-gated ion channels, which are pivotal in regulating electrical activity in excitable cells and are critical pharmaceutical targets for treating many diseases, including cardiac arrhythmias and neuropathic pain. The LSRG Committee has evaluated over five hundred applications during this review cycle. And selected 19 projects for funding.
Society welcomes inaugural Editors-in-Chief for The Journal of Precision Medicine: Health and Disease and The Journal of Nutritional Physiology
Following the announcement of The Physiological Society’s partnership with Elsevier to launch a new journal, we are delighted to introduce the Editor-in-Chief (Colleen E. Clancy) and Deputy Editor in Chief (Vladimir Yarov-Yarovoy) of The Journal of Precision Medicine: Health and Disease.