Gabriela G. Loots,
Professor
Locations and Contact
Oak Park Research Center Building
Oak Park Research Center Building
2700 Stockton Blvd.
Sacramento, CA 95817
Additional Numbers
Clinic Phone
Research/Academic Interests
Dr. Loot's group is interested in understanding how functional elements are encoded in the human genome and how proteins and transcriptional regulatory elements orchestrate tissue- and cell-type specific gene regulatory networks that contribute to susceptibility to bone and cartilage degenerative disorders such as osteoporosis and arthritis. They use comparative genomics, genetic engineering, bioinformatics analysis, single cell RNAseq, and other high throughput genomic approaches to test our genomic-driven hypotheses. Their studies emphasize on the role of Wnt Signaling in bone, cartilage and cancer.
Division
Orthopaedic Research
Undergraduate School
B.S., Developmental Biology/Genetics, UC Irvine, Irvine CA 1996
Other School
Ph.D., Molecular and Cell Biology, UC Berkeley, Berkeley CA 2000
Fellow, American Society for Bone and Mineral Research, 2021
Excellence in Publication Award, Lawrence Livermore National Laboratory, 2021
Mid-Career Award, Lawrence Livermore National Laboratory, 2018
Best Faculty Talk, UC Merced-Quantitative Systems Biology Graduate Group, 2016
Complete List of My Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/1T71bgbHAAKAX/bibliography/public/
Sebastian A, Hum NR, McCool JL, Wilson SP, Murugesh DK, Martin KA, Rios-Arce ND, Amiri B, Christiansen BA, Loots GG. Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis. Front Immunol. 2022 Jul 29;13:938075. doi:10.3389/fimmu.2022.938075. PMID:35967299.
Rios-Arce ND, Murugesh DK, Hum NR, Sebastian A, Jbeily EH, Christiansen BA, Loots GG. Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis. JBMR Plus. 2022 Apr 19;6(5):e10625. doi:10.1002/jbm4.10625. PMID:35509635.
Sebastian A, McCool JL, Hum NR, Murugesh DK, Wilson SP, Christiansen BA, Loots GG. Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. Cells. 2021 Jun 10;10(6):1462. doi:10.3390/cells10061462. PMID:34200880.
Mendez ME, Sebastian A, Murugesh DK, Hum NR, McCool JL, Hsia AW, Christiansen BA, Loots GG. LPS-Induced Inflammation Prior to Injury Exacerbates the Development of Post-Traumatic Osteoarthritis in Mice. J Bone Miner Res. 2020 Nov;35(11):2229-2241. doi:10.1002/jbmr.4117. Epub 2020 Aug 3. PMID:32564401.
Sebastian A, Hum NR, Martin KA, Gilmore SF, Peran I, Byers SW, Wheeler EK, Coleman MA, Loots GG. Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer. Cancers (Basel). 2020 May 21;12(5):1307. doi:10.3390/cancers12051307. PMID:32455670.
Hum NR, Martin KA, Malfatti MA, Haack K, Buchholz BA, Loots GG. (2018). Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry. Sci Reports. 2018 Oct 9 (Epub).
Yee CS, Manilay JO, Chang JC, Hum NR, Murugesh DK, Bajwa J, Mendez ME, Economides AE, Horan DJ, Robling AG, Loots GG. Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development. J Bone Miner Res. 2018 Oct;33(10):1748-1759. doi:10.1002/jbmr.3467. Epub 2018 Jun 29. PMID:29750826.
Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG. SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. J Bone Miner Res. 2018 Jun;33(6):1105-1113. doi:10.1002/jbmr.3397. Epub 2018 Apr 2. PMID:29377313.
Sebastian A, Hum NR, Murugesh DK, Hatsell S, Economides AN, Loots GG. Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts. PLoS One. 2017 Nov 27;12(11):e0188264. doi:10.1371/journal.pone.0188264. PMID:29176883.