Thomas H. Ambrosi, Ph.D., M.S., Dipl.Ing.
Assistant Professor
Locations and Contact
Oak Park Research Center Building
Oak Park Research Center Building
2700 Stockton Blvd.
Sacramento, CA 95817
Additional Numbers
Clinic Phone
Research/Academic Interests
Dr. Ambrosi's research focuses on the interactions of skeletal and hematopoietic cellular lineages in postnatal bones of mice and humans using a stem cell-centric approach. Interrogating skeletal stem cell biology during development, aging and cancer/disease allows us to dissect the cellular niches and molecular signals maintaining hematopoietic stem cells and regulating immune cell output. Previous and ongoing work has comprehensively investigated SSC biology during mouse and human development as well as how alterations in the SSC compartment drive aging and oncogenic malignancies by cell-autonomous processes and multi-stem cell system crosstalk (bone-blood). Our long-term goal is to develop strategies to prevent and reverse SSC-based bone and hematopoietic aging and malignancies.
Division
Orthopaedic Research
Undergraduate School
Pre-diploma, Medical Biotechnology, Technische Universität Berlin, Berlin, Germany 2010
Medical School
Dipl.Ing., Medical Biotechnology, Technische Universität Berlin, Berlin, Germany 2013
Other School
M.S., Bionengineering, Dongseo University, Busan, South Korea 2013
Other School
Ph.D., Pathobiochemistry & Stem Cell Biology, University of Potsdam, Potsdam, Germany 2017
Fellowship
Surgery/Postdoc, Stanford University, Palo Alto CA 2017-2022
John Haddad Young Investigator Award, American Society for Bone and Mineral Research, 2022
ASBMR Young Investigator Award, American Society for Bone and Mineral Research, 2021
Young Investigator Travel & Merit Award, International Society for Stem Cell Research, 2019, 2021
Best Oral Presentation Award, Bone Marrow Adiposity Society, 2019, 2020
Best Dissertation Awards, "Michelson Award" by the University of Potsdam and "Best Thesis Award" by the Berlin School of Regenerative Medicine (BSRT), Charité Berlin, 2017
Access Dr. Ambrosi's bibliography here.
Goodnough LH, Ambrosi TH, Steininger HM, Butler MGK, Hoover MY, Choo H, Van Rysselberghe NL, Bellino MJ, Bishop JA, Gardner MJ, Chan CKF. Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs. Front Endocrinol (Lausanne). 2022 Aug 25;13:924927. doi:10.3389/fendo.2022.924927. PMID:36093067.
Ambrosi TH, Chan CKF. Skeletal Stem Cells as the Developmental Origin of Cellular Niches for Hematopoietic Stem and Progenitor Cells. Curr Top Microbiol Immunol. 2021;434:1-31. doi:10.1007/978-3-030-86016-5_1. PMID:34850280.
Ambrosi TH, Marecic O, McArdle A, Sinha R, Gulati GS, Tong X, Wang Y, Steininger HM, Hoover MY, Koepke LS, Murphy MP, Sokol J, Seo EY, Tevlin R, Lopez M, Brewer RE, Mascharak S, Lu L, Ajanaku O, Conley SD, Seita J, Morri M, Neff NF, Sahoo D, Yang F, Weissman IL, Longaker MT, Chan CKF. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature. 2021 Sep;597(7875):256-262. doi:10.1038/s41586-021-03795-7. Epub 2021 Aug 11. PMID:34381212.
Ambrosi TH, Sinha R, Steininger HM, Hoover MY, Murphy MP, Koepke LS, Wang Y, Lu WJ, Morri M, Neff NF, Weissman IL, Longaker MT, Chan CK. Distinct skeletal stem cell types orchestrate long bone skeletogenesis. Elife. 2021 Jul 19;10:e66063. doi:10.7554/eLife.66063. PMID:34280086.
Murphy MP, Koepke LS, Lopez MT, Tong X, Ambrosi TH, Gulati GS, Marecic O, Wang Y, Ransom RC, Hoover MY, Steininger H, Zhao L, Walkiewicz MP, Quarto N, Levi B, Wan DC, Weissman IL, Goodman SB, Yang F, Longaker MT, Chan CKF. Articular cartilage regeneration by activated skeletal stem cells. Nat Med. 2020 Oct;26(10):1583-1592. doi:10.1038/s41591-020-1013-2. Epub 2020 Aug 17. PMID:32807933.
Ambrosi TH, Goodnough LH, Steininger HM, Hoover MY, Kim E, Koepke LS, Marecic O, Zhao L, Seita J, Bishop JA, Gardner MJ, Chan CKF. Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell. 2020 Jul;19(7):e13164. doi:10.1111/acel.13164. Epub 2020 Jun 14. PMID:32537886.
Ambrosi TH, Longaker MT, Chan CKF. A Revised Perspective of Skeletal Stem Cell Biology. Front Cell Dev Biol. 2019 Sep 13;7:189. doi:10.3389/fcell.2019.00189. PMID:31572721.
Chan CKF, Gulati GS, Sinha R, Tompkins JV, Lopez M, Carter AC, Ransom RC, Reinisch A, Wearda T, Murphy M, Brewer RE, Koepke LS, Marecic O, Manjunath A, Seo EY, Leavitt T, Lu WJ, Nguyen A, Conley SD, Salhotra A, Ambrosi TH, Borrelli MR, Siebel T, Chan K, Schallmoser K, Seita J, Sahoo D, Goodnough H, Bishop J, Gardner M, Majeti R, Wan DC, Goodman S, Weissman IL, Chang HY, Longaker MT. Identification of the Human Skeletal Stem Cell. Cell. 2018 Sep 20;175(1):43-56.e21. doi:10.1016/j.cell.2018.07.029. PMID:30241615.
Ambrosi TH, Schulz TJ. The emerging role of bone marrow adipose tissue in bone health and dysfunction. J Mol Med (Berl). 2017 Dec;95(12):1291-1301. doi:10.1007/s00109-017-1604-7. Epub 2017 Nov 3. PMID:29101431.