Clinical Epidemiology Core

Mission

Welcome to the UC Davis Health System’s Center for Musculoskeletal Health’s Clinical Epidemiology Core. The mission of the Clinical Epidemiology Core is to perform and facilitate epidemiologic research into causes of, therapies for, and outcomes from various musculoskeletal diseases and conditions. Besides performing studies and analyses, we also coordinate, assist and organize with collaborators across the country and around the world, often to allow for large multicenter and interdisciplinary projects that require many kinds of expertise. Most studies in osteoarthritis and some other musculoskeletal diseases require large numbers of subjects for studies as well as significant contributions related to radiologic imaging, computer programming and image analysis, and sophisticated epidemiologic approaches, and the Clinical Epidemiology Core provides these. We also train and employ biostatisticians who have specific experience and expertise in working on problems related to musculoskeletal health, longitudinal analysis and trajectory analysis, and analysis related to complex imaging techniques and scoring.

Resources

Besides Dr. Wise (Associate Director of the Clinical Epidemiology Core) and Dr. Lane, the Epidemiology Core also includes other faculty, including Dr. Heejung Bang, biostatistician. The Core trains and employs several analysts and biostatisticians, both at UC Davis and elsewhere: these analysts have specific expertise in working with questions related to osteoarthritis and disease incidence and progression; pain fluctuations; imaging modalities including MRI and WORMS and MOAKS scoring, T2 relaxation time and T1Rho, joint CT, and plain radiography; questions related to joint analysis; functional impairment and disability analysis; Active Shape Modeling; pharmacoepidemiology. The Core also employs, trains and oversees computer programmers and research specialists in preparing body and joint imaging for analysis. The Core has contributed and continues to contribute a large array of readings for plain radiograph, MRI, and Active Shape Modeling to large public arthritis datasets includingthe Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI).

Synergy and Collaboration with Other Cores in the Center for Musculoskeletal Health

The Clinical Epidemiology Core works closely with the Center for Musculoskeletal Health’s Research Laboratory, Imaging Core, and Clinical Trials Core, reflecting the essentially interdisciplinary and translational nature of the research we perform. Imaging-related questions are intrinsic to the work that the Core performs, and the Clinical Epidemiology Core provides guidance for approaches for the Imaging Core, and frequently analysis. The Epidemiology Core has collaborated with the Center’sResearch Laboratory on multiple projects, including measuring nerve growth factor and uric acid concentrations in subjects for several large cohort studies. Finally, the Epidemiology Core works closely with the Clinical Trials group, including several projects being set up now for potential interventions.

Clinical Work

The Core’s primary mission is research and training of new researchers and others, but Dr’s Wise and Lane continue to see patients and remain active clinically, in both the outpatient clinic and in the inpatient hospital setting.

Selected Publications

1. Wise BL, Felson DT, Clancy M, Niu J, Neogi T, Lane N, Hietpas J, Curtis J, Bradley L, Torner J, Zhang YQ. Consistency of Knee Pain and Risk of Knee Replacement: the MOST Study. J Rheumatol 2011;38;1390-1395.
2. Kim SH, Wise BL, Zhang Y, Szabo R. Increasing incidence of shoulder arthroplasty. J Bone Joint Surg Am. 2011 Dec 21;93(24):2249-54.
3. Wise BL, Yang M, Niu J, Lane NE, Harvey W, Felson DT, Nevitt M, Hietpas J, Torner J, Lewis CE, Zhang Y. Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans. Arthritis Care Res. 2012 Jun;64(6):847-52.
4. Wise BL, Peloquin C, Choi H, Lane NE, Zhang Y. Impact of age, gender, obesity, and steroid use on quinolone-associated tendon disorders. American Journal of Medicine. 2012;125(12):1228.e23–e28.
5. Wise BL, Parimi N, Zhang Y, Cawthon P, Barrett-Connor E, Ensrud K, Lane NE for the Osteoporotic Fractures in Men (MrOS) Research Group. Frailty and Hip Osteoarthritis in Men in the MrOS Cohort. PMID: 24253535 PMCID: PMC3991147 DOI: 10.1093/gerona/glt126.
6. Seidel M*, Wise BL* (Co-Equal First Authors), Lane NE. Nerve Growth Factor: An Update on the Science and Therapy. 2013. PMID: 23973134 PMCID: PMC4252012 DOI: 10.1016/j.joca.2013.06.004.
7. Maxwell JL, Keysor JJ, Niu J, Singh JA, Wise BL, Frey-Law L, Nevitt MC, Felson DT.Participation following knee replacement: The MOST Cohort Study. Phys Ther. 2013. PMID: 23813082 PMCID: PMC3827713 DOI: 10.2522/ptj.20130109.
8. Maxwell JL, Felson DT, Niu J, Wise B, Nevitt M, Singh J, Frey-Law L, Neogi T.Does Important Improvement in Function After Knee Replacement Guarantee Good Absolute Function. 2013. PMID: 24293582 PMCID: PMC3914207 DOI: 10.3899/jrheum.130313
9. Wise BL, Niu J, Zhang Y, Felson DT, Bradley L, Torner J, Nevitt M, Lane NE. The association of parity with osteoarthritis and knee replacement in the multicenter osteoarthritis study. PMID: 24029601 PMCID: PMC3855897 DOI: 10.1016/j.joca.2013.08.025.
10. Wise BL, Parimi N, Zhang Y, Cawthon P, Barrett-Connor E, Ensrud K, Lane NE for the Osteoporotic Fractures in Men (MrOS) Research Group. Frailty and Hip Osteoarthritis in Men in the MrOS Cohort. J Gerontol A Biol Sci Med Sci 2014;69(5):602–608. PMID: 24253535. PMCID:PMC3991147.
11. Seidel M*, Wise BL* (Co-Equal First Authors), Lane NE. Nerve Growth Factor: An Update on the Science and Therapy. Osteoarthritis and Cartilage. 2013;21(9):1223-8. PMID:23973134. PMCID:PMC4252012.
12. Maxwell JL, Keysor JJ, Niu J, Singh JA, Wise BL, Frey-Law L, Nevitt MC, Felson DT. Participation following knee replacement: The MOST Cohort Study. Phys Ther. 2013;93(11):1467-74. PMCID: PMC3827713.
13. Maxwell JL, Felson DT, Niu J, Wise B, Nevitt M, Singh J, Frey-Law L, Neogi T. Does Important Improvement in Function After Knee Replacement Guarantee Good Absolute Function. J Rheumatol. 2014;41(1):60-4. PMCID:PMC3914207
14. Wise BL, Niu J, Zhang Y, Felson DT, Bradley L, Torner J, Nevitt M, Lane NE. The association of parity with knee osteoarthritis and total knee replacement in the MOST cohort. Osteoarthritis Cartilage. 2013;21(12):1849-54. PMCID: PMC3855897.
15. Lane NE, Parimi N, Lui L, Wise BL, Yao W, Lay YA, Cawthon PM, Orwoll E; for the Osteoporotic Fractures in Men (MrOS) Study Group. Association of Serum Uric Acid and Incident Nonspine Fractures in Elderly Men: The Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res. 2014;29(7):1701-7. PMID: 24347506. PMCID: PMC4351860.
16. Chaudhari AJ, Leahy RM, Wise BL, Lane NE, Badawi RD, Joshi AA. Global point signature for shape analysis of carpal bones. Physics in Medicine and Biology. 2014; 59(4):961-973. PMCID:PMC3966902.
17. Boissonneault A, Lynch JA, Wise BL, Segal NA, Gross KD, Murray DW, Nevitt MC, Pandit HG. Association of hip and pelvic geometry with tibiofemoral osteoarthritis: Multicenter Osteoarthritis Study (MOST). Osteoarthritis and Cartilage. 2014;22(8):1129-35. PMID: 24971867. PMCID:PMC4195737.
18. Wise BL, Kritikos L, Lynch JA, Liu F, Parimi P, Luker Tileston K, Nevitt N, Lane NE. Proximal Femur Shape Differs Between Subjects with Lateral and Medial Knee Osteoarthritis and Controls: The Osteoarthritis Initiative. Osteoarthritis and Cartilage. 2014;22(12):2067-73. PMID:25194496. PMCID:PMC4252863.
19. Wise BL, Niu J, Felson DT, Hietpas J, Sadosky A, Torner J, Lewis CE, Nevitt M. Functional Impairment As a Predictor of Knee Replacement in the Multicenter Osteoarthritis Study. Clinical Orthopaedics and Related Research. 2015;473(8):2505-13. PMID: 25754756. PMCID:PMC4488226.
20. Heiman E, Kravitz RL, Wise BL. Rheumatologists’ Approaches to Diagnosis and Treatment of Depression. Manuscript Accepted November 2015 at Journal of Clinical Rheumatology.
21. Wise BL, Liu F, Kritikos L, Lynch JA, Parimi N, Zhang Y, Lane NE. The association of distal femur and proximal tibia shape with sex: the Osteoarthritis Initiative. Semin Arthritis Rheum. 2016 Aug;46(1):20-6. PMID: 27039962. PMCID: PMC4969176 [Available in PMC on 2017-08-01].
22. Skou ST, Wise BL, Lewis CE, Felson DT, Nevitt M, Segal NA, for the Multicenter Osteoarthritis Study Group. Muscle strength, physical performance and physical activity as predictors of future total knee replacement: A prospective cohort study. Published by Elsevier Ltd. All rights reserved. PMID: 27066879 PMCID: PMC4955690 [Available on 2017-08-01] DOI: 10.1016/j.joca.2016.04.001.
23. Wise BL, Niu J, Guermazi A, Liu F, Heilmeier U, Ku E, Lynch JA, Zhang Y, Felson DT, Kwoh K, Lane NE. Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease - data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Aug 15. pii: S1063-4584(16)30232-1. doi: 10.1016/j.joca.2016.08.002. PMID: 27539891.
24. Lane NE, Shidara K, Wise BL. Osteoarthritis year in review 2016: Clinical. Manuscript accepted at Osteoarthritis and Cartilage, September 2016.
25. Carlesso LC, Segal N, Curtis JR, Wise BL, Frey-Law L, Nevitt MC, Neogi T. Knee Pain Severity Rather Than Structural Damage is a Risk Factor for Incident Widespread Pain: The Multicenter Osteoarthritis (MOST) Study. Arthritis Care Res. 2016 Sep 16. doi: 10.1002/acr.23086. PMID: 27636245.