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Wei Yao, M.D.
Professor
Specialties
Metabolic Bone Disease
Musculoskeletal Disorders
Bone and Joint
Department
Locations and Contact
UC Davis Medical Center
UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, CA 95817
Phone: 800-2-UCDAVIS (800-282-3284)
Research/Academic Interests
Dr, Yao's research focuses on drug discovery and translational studies on bone and joint disorders. She also studies factors affecting the sex differences in musculoskeletal system, including progesterone receptor and Wnt signaling. For the past two decades, she has been working with Dr. Nancy Lane to define factors affecting bone qualities that are independent from bone quantities, including the effects of glucocorticoids and bisphosphonates.
Division
Rheumatology, Allergy and Clinical Immunology
Medical School
M.D., Xiangya Medical University, ChangSha, China 1992
Other School
M.S., Pulmonary, Xiangya Medical University, ChangSha, China 1997
Internship
Radiation, University of Utah, Salt Lake City UT 1997-2000
Betterment of Mankind Award, The Pauchon Research Foundation, 2016
Dean’s Team Award, Excellency in Research, UC Davis School of Medicine, 2013
UC Davis Academic Federal Excellency in Research Award, 2012
Mentor Award, Internal Medicine, UC Davis Medical Center, 2011
American Society of Bone and Mineral Research Young Investigator Award, 2003
Jiang M, Liu L, Liu R, Lam KS, Lane NE, Yao W. A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation. BMC Pharmacol Toxicol. 2020 Nov 13;21(1):76. doi:10.1186/s40360-020-00454-x. PMID:33187558.
Jiang M, Liu R, Liu L, Kot A, Liu X, Xiao W, Jia J, Li Y, Lam KS, Yao W. Identification of osteogenic progenitor cell-targeted peptides that augment bone formation. Nat Commun. 2020 Aug 27;11(1):4278. doi:10.1038/s41467-020-17417-9. PMID:32855388.
Liu LX, Jia JJ, Jiang M, Liu XP, Dai CL, Wise BL, Lane NE, Yao W. High susceptibility to collagen-induced arthritis in mice with progesterone receptors selectively inhibited in osteoprogenitor cells. Arthritis Res Ther. 2020 Mar;22:165. doi:10.1186/s13075-020-02242-8.
Dai C, Jia J, Kot A, Liu X, Liu L, Jiang M, Lane NE, Wise BL, Yao W. Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures. Bone. 2020 Mar;132:115196. doi:10.1016/j.bone.2019.115196. Epub 2019 Dec 19. PMID:31863959.
Yao W, Lay YE, Kot A, Liu R, Zhang H, Chen H, Lam K, Lane NE. Improved Mobilization of Exogenous Mesenchymal Stem Cells to Bone for Fracture Healing and Sex Difference. Stem Cells. 2016 Oct;34(10):2587-2600. doi:10.1002/stem.2433. Epub 2016 Jul 15. PMID:27334693.
Yao W, Dai W, Jiang L, Lay EY, Zhong Z, Ritchie RO, Li X, Ke H, Lane NE. Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength. Osteoporos Int. 2016 Jan;27(1):283-294. doi:10.1007/s00198-015-3308-6. Epub 2015 Sep 18. PMID: 26384674.
Zhong ZA, Sun W, Chen H, Zhang H, Lay YE, Lane NE, Yao W. Optimizing tamoxifen-inducible Cre/loxp system to reduce tamoxifen effect on bone turnover in long bones of young mice. Bone. 2015 Dec;81:614-619. doi:10.1016/j.bone.2015.07.034. Epub 2015 Jul 29. PMID:26232373.
Dai W, Jiang L, Lay YA, Chen H, Jin G, Zhang H, Kot A, Ritchie RO, Lane NE, Yao W. Prevention of glucocorticoid induced bone changes with beta-ecdysone. Bone. 2015 May;74:48-57. doi:10.1016/j.bone.2015.01.001. Epub 2015 Jan 10. PMID:25585248.
Yao W, Lane NE. Targeted delivery of mesenchymal stem cells to the bone. Bone. 2015 Jan;70:62-5. doi:10.1016/j.bone.2014.07.026. Epub 2014 Aug 28. PMID:25173607.
Yao W, Dai W, Jiang JX, Lane NE. Glucocorticoids and osteocyte autophagy. Bone. 2013 Jun;54(2):279-84. doi:10.1016/j.bone.2013.01.034. Epub 2013 Jan 26. PMID:23356984.