September 2019 - Presented by Miao Tian (Mentored by Karen Matsukuma)

Clinical History

A 65-year-old man presented with one week of non-radiating right lower quadrant abdominal pain associated with nausea, vomiting, and anorexia. CT on admission showed acute non-perforated appendicitis. He was subsequently taken to the OR for laparoscopic appendectomy. Intraoperatively he was found to have perforated appendicitis with murky, purulent fluid throughout the abdomen.

Histology

Figure 1
Figure 1

Figure 2
Figure 2

Figure 3
Figure 3

Figure 4. CDX2
CDX2

Figure 5. Synaptophysin
Synaptophysin

What is most likely the diagnosis?

Choose one answer and submit.





 

The correct answer is:

D.)

Low-grade appendiceal goblet cell adenocarcinoma (LG-GCAC) (formerly typical goblet cell carcinoid) is a mixed endocrine-exocrine neoplasm almost exclusively seen in the appendix.

> Learn more about this diagnosis.