Padmini Sirish, Ph.D. for UC Davis Health

Padmini  Sirish, Ph.D.

Padmini Sirish, Ph.D.

Adjunct Associate Professor, Department of Internal Medicine

Padmini Sirish is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Reviews

Specialties

Cardiovascular Research

Department

Internal Medicine

Locations and Contact

Genome and Biomedical Sciences Building

Genome & Biomedical Sciences Facility
451 Health Sciences Dr
Davis, CA 95616

Get Directions

Phone: 530-752-2884

Research/Academic Interests

Dr. Sirish's research is centered on developing novel therapies for heart failure with a focus on cardiac regenerative therapy using stem cells and seeking new therapeutic targets in the inflammatory pathways for heart failure with preserved ejection fraction (HFpEF). Dr. Sirish focuses on targeting novel inflammatory proteins in cardiac stem cell-therapy as a treatment option for end-stage heart failure. 

Division

Cardiovascular Medicine

Undergraduate School

B.S./M.S., Biotechnology and Cytogenetics, Bangalore University, India 2000

Other School

Ph.D., Molecular, Cellular and Integrative Physiology, UC Davis, Davis CA 2011

Department of Internal Medicine Chair’s Research Award, UC Davis, 2023,

Department of Internal Medicine Outstanding Contribution to Science Award, UC Davis, 2019,

TRDRP New Investigator Grant, 2022-2026,

Loren D Carlson Award in Physiology, UC Davis, 2011,

Access Padmini Sirish's full bibliography here: https://www.ncbi.nlm.nih.gov/myncbi/padmini.sirish.1/bibliography/public/

Yamoah M, Moshref M, Sharma J, Chen WC, Ledford HA, Lee JH, Chavez KS, Wang W, López JE, Lieu DK, Sirish P*, Zhang X*. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. International Journal of Nanomedicine; (*Co-corresponding authors) 2018 Oct 5;13:6073-6078. PMID: 30323594  

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 Jun 4;129(8):3140-3152. PMID: 31162142 

Sirish P, Lee J, Yang J, Zhang X, Thai P, Li N, Timofeyev V, Lee KSS,. Nader C, Haddad M, Timofeyeva M, Rowland D, Yechikov S, Ganaga S,Young  JN, Lieu DK,  Yamoah E, Hammock BD and Chiamvimonvat N. New treatment paradigm to enhance cardiac cell-based therapy. Stem Cell Translational Medicine, Aug 13, 2020.PMID: 32790136

Prada MP, Syed A, Reddy G, Baudel MMA, Tamez VAF, Sasse JC, Ward SM, Sirish P, Chiamvimonvat N,  Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo M, and Cintrón M.  AKAP5 complex in purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Comm, 2020: 1-15. 

Dehghani T, Thai P, Sodhi H, Ren L, Sirish P, Nader C, Timofeyev V, Li X, Lam KS, Chiamvimonvat N and Panitch A. Selectin-Targeting Glycosaminoglycan-Peptide Conjugate Limits Cardiac Injury After Myocardial Infarction by Abating Neutrophil Recruitment. Cardiovascular Research. 2020 Oct 30; PMID: 33125066

Yechikov S, Kao H, Chang CE, Pretto D, Zhang XD, Sun YH, Smithers R, Sirish P, Nolta JA, Chan JA, Chiamvimonvat N, and Lieu DK. Nodal inhibition promotes differentiation of pacemaker-like cardiomyocytes from human induced pluripotent stem cells. Stem Cell Reports. 2020 Dec;49:102043 PMID: 33128951

Ledford H, Park S, Muir D, Woltz R, Ren L, Nguyen P, Sirish P, Wang W, Sihn CR, George A, Knollmann B, Yamoah E, Yarov-Yarovoy V, Zhang XD, Chiamvimonvat N. Different arrhythmia-associated calmodulin mutations have different effects on cardiac SK channel regulation. Journal of General Physiology. 2020 Dec 7;152(12) PMID: 33211795

Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Yang J, Hammock B, Chiamvimonvat N, and Sirish P*. Chronic Diclofenac Exposure Impairs Cardiac Function via Mitochondrial Oxidative Stress. Cardiovascular Drugs and Therapy. 2021 Sept 9. PMCID: PMC8904649

Sirish P, Diloretto D, That PT, Chiamvimonvat N. The critical roles of proteostasis and endoplasmic reticulum stress in atrial fibrillation. Frontiers in Physiology. 2022 Jan 4;12:793171. PMCID: PMC8764384

Ledford HA, Ren L, Thai P, Park s, Timofeyev V, Sirish P, Xu W, Emigh A, Priest J, Perez M, Ashley E, Yarov-Yarovoy V, Yamoah E, Zhang X, Chiamvimonvat C. Disruption of protein quality control of the human ether-a-go-go related gene K+ channel results in profound long QT syndrome. Heart Rhythm. 2022 Feb;19(2):281-292. PMCID: PMC8810706