Pathology
Rheumatology
Rheumatology, Allergy and Clinical Immunology
Dr. Tsuneyama's research focuses on elucidating the pathogenic mechanism of autoimmune-related liver diseases, especially primary biliary cholangitis using new model animals. He is also interested in liver disease associated with metabolic syndrome.
Rheumatology, Allergy and Clinical Immunology
M.D., Kanazawa University School of Medicine, Kanazawa, lshikawa, Japan 1992
Ph.D., Kanazawa University Graduate School, Kanazawa, lshikawa, Japan 1996
Pathology, Toyama City Hospital, Toyama, Japan 1997
Pathology, Kanazawa University School of Medicine, Kanazawa, lshikawa, Japan 1998
Scientific Research Award, Japanese Society of Pathology, 2016
Research Award for Young Hepatologists, Japan Society of Hepatology, 1999
Miyazaki K, Morine Y, Imura S, Ikemoto T, Saito Y, Yamada S, Tokuda K, Okikawa S, Yamashita S, Oya T, Tsuneyama K, Shimada M. Preoperative lymphocyte/C-reactive protein ratio and its correlation with CD8+ tumor-infiltrating lymphocytes as a predictor of prognosis after resection of intrahepatic cholangiocarcinoma. Surg Today. 2021 May 19. doi:10.1007/s00595-021-02295-5. Epub ahead of print. PMID:34009433.
Yamashita S, Morine Y, Imura S, Ikemoto T, Saito Y, Takasu C, Yamada S, Tokuda K, Okikawa S, Miyazaki K, Oya T, Tsuneyama K, Shimada M. A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2. World J Surg Oncol. 2021 May 7;19(1):142. doi:10.1186/s12957-021-02216-3. PMID:33962620.
Ichimura-Shimizu M, Omagari K, Yamashita M, Tsuneyama K. Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis. Biosci Biotechnol Biochem. 2021 Mar 24;85(4):941-947. doi:10.1093/bbb/zbaa107. PMID:33620426.
Shimoyama S, Kawata K, Ohta K, Chida T, Suzuki T, Tsuneyama K, Shimoda S, Kurono N, Leung PSC, Gershwin ME, Suda T, Kobayashi Y. Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis. Eur J Immunol. 2021 Mar 12. doi:10.1002/eji.202048589. Epub ahead of print. PMID:33710617.
Matsumoto K, Kikuchi K, Hara A, Tsunashima H, Tsuneyama K, Doi S. Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma. Clin J Gastroenterol. 2021 Jun;14(3):827-830. doi:10.1007/s12328-021-01354-1. Epub 2021 Feb 10. PMID:33566306.
Tanaka H, Saijo Y, Tomonari T, Tanaka T, Taniguchi T, Yagi S, Okamoto K, Miyamoto H, Sogabe M, Sato Y, Muguruma N, Tsuneyama K, Sata M, Takayama T. An Adult Case of Congenital Extrahepatic Portosystemic Shunt Successfully Treated with Balloon-occluded Retrograde Transvenous Obliteration. Intern Med. 2021 Jan 15. doi:10.2169/internalmedicine.5914-20. Epub ahead of print. PMID:33456037.
Umezu T, Tsuneyama K, Kanekura K, Hayakawa M, Tanahashi T, Kawano M, Taguchi YH, Toyoda H, Tamori A, Kuroda M, Murakami Y. Comprehensive analysis of liver and blood miRNA in precancerous conditions. Sci Rep. 2020 Dec 10;10(1):21766. doi:10.1038/s41598-020-78500-1. PMID:33303811.
Minamikawa T, Ichimura-Shimizu M, Takanari H, Morimoto Y, Shiomi R, Tanioka H, Hase E, Yasui T, Tsuneyama K. Molecular imaging analysis of microvesicular and macrovesicular lipid droplets in non-alcoholic fatty liver disease by Raman microscopy. Sci Rep. 2020 Oct 29;10(1):18548. doi:10.1038/s41598-020-75604-6. PMID:33122711.
Kondo M, Izawa-Ishizawa Y, Goda M, Hosooka M, Kagimoto Y, Saito N, Matsuoka R, Zamami Y, Chuma M, Yagi K, Takechi K, Tsuneyama K, Ishizawa K. Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice. Int J Mol Sci. 2020 Sep 30;21(19):7226. doi:10.3390/ijms21197226. PMID:33007902.
Matsumoto M, Tsuneyama K, Morimoto J, Hosomichi K, Matsumoto M, Nishijima H. Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms. Int Immunol. 2020 Feb 7;32(2):117-131. doi:10.1093/intimm/dxz066. PMID:31586207.