Carroll E. Cross, M.D.
Emeritus Professor, Departments of Internal Medicine and Physiology and Membrane Biology
Carroll E. Cross is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Locations and Contact
Genome and Biomedical Sciences Building
Genome & Biomedical Sciences Facility
451 Health Sciences Dr
Davis, CA 95616
Phone: 530-752-2884
Philosophy of Care
Dr. Carroll Cross is an academic clinician with expertise in pulmonary medicine and physiology with a focus on cystic fibrosis and congenital emphysema. He is aggressive about facilitating the challenges inherent in successfully translating the latest relevant aspects of laboratory research to clinical medicine, patient management, and health.
Clinical Interests
Dr. Carroll Cross is a medical scientist with a particular interest and expertise in lung biology and medicine, focusing on Cystic Fibrosis and congenital emphysema (alpha-2 antitrypsin deficiency). He finds it particularly rewarding to stay up to date regarding the latest laboratory and clinical studies related to these conditions. He passionately attempts to participate in research aspects of the diseases he cares for in the clinic.
Research/Academic Interests
Dr. Carroll Cross's past research interests focused on selected aspects of pulmonary physiology ad free radical biology and medicine. His more recent research contributions relate to cystic fibrosis and congenital emphysema communities. His most recent research activities are related to liason with the outstanding UC Davis chemical engineering and plant genetics "Planta Pharma" program to develop plant production of human alpha-1 antitrypsin for the treatment of congenital emphysema.
Division
Undergraduate School
B.A., Chemistry, Pomona College, Claremont CA 1957
Medical School
M.D., Columbia University, College of Physicians and Surgeons, New York NY 1961
Other School
Medicine, University of Washington, Seattle WA 1958
Internship
Internal Medicine, University of Wisconsin, Madison WI 1961-1962
Residency
Internal Medicine, Stanford University, School of Medicine, Palo Alto CA 1962-1964
Fellowship
Pulmonary Fellowship, University of Pittsburgh, Pittsburgh PA 1964-1968
Distinguished Research Career Award, UC Davis Department of Medicine, 2015
Distinguished Professor, UC Davis, 2007
Deans Award, UC Davis School of Medicine, 2002
California Medal of the California Lung Association, 1999
UC Davis School of Medicine Faculty Research Award for Excellence in Clinical Research, 1980
McNulty MJ, Silberstein DZ, Kuhn BT, Padgett HS, Nandi S, McDonald KA, Cross CE. Alpha-1 antitrypsin deficiency and recombinant protein sources with focus on plant sources: Updates, challenges and perspectives. Free Radic Biol Med. 2021 Feb 1;163:10-30. doi:10.1016/j.freeradbiomed.2020.11.030. Epub 2020 Dec 3. PMID:33279618.
Reverri EJ, Morrissey BM, Cross CE, Steinberg FM. Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis. Free Radic Biol Med. 2014 Nov;76:261-77. doi:10.1016/j.freeradbiomed.2014.08.005. Epub 2014 Aug 27. PMID:25172163.
Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Halliwell B, van der Vliet A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature. 1998 Jan 22;391(6665):393-7. doi:10.1038/34923. PMID:9450756.
van der Vliet A, Eiserich JP, Halliwell B, Cross CE. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity. J Biol Chem. 1997 Mar 21;272(12):7617-25. doi:10.1074/jbc.272.12.7617. PMID:9065416.
Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J. 1991 Jul 1;277 ( Pt 1)(Pt 1):133-8. doi:10.1042/bj2770133. PMID:1854329.
Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, McCord JM, Harman D. Oxygen radicals and human disease. Ann Intern Med. 1987 Oct;107(4):526-45. doi:10.7326/0003-4819-107-4-526. PMID:3307585.
Cross CE, Halliwell B, Allen A. Antioxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet. 1984 Jun 16;1(8390):1328-30. doi:10.1016/s0140-6736(84)91822-1. PMID:6145029.
DeLucia AJ, Mustafa MG, Hussain MZ, Cross CE. Ozone interaction with rodent lung. III. Oxidation of reduced glutathione and formation of mixed disulfides between protein and nonprotein sulfhydryls. J Clin Invest. 1975 Apr;55(4):794-802. doi:10.1172/JCI107990. PMID:1120782.
Cross CE, Gong H Jr, Kurpershoek CJ, Gillespie JR, Hyde RW. Alterations in distribution of blood flow to the lung's diffusion surfaces during exercise. J Clin Invest. 1973 Feb;52(2):414-21. doi:10.1172/JCI107198. PMID:4683880.
Cross CE, Packer BS, Altman M, Gee JB, Murdaugh HV Jr, Robin ED. The determination of total body exchangeable O2 stores. J Clin Invest. 1968 Oct;47(10):2402-10. doi:10.1172/JCI105923. PMID:4877683.