Lisa Madden, M.D.
Associate Professor
To see if Lisa Madden is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Locations and Contact
UC Davis Comprehensive Cancer Center
UC Davis Comprehensive Cancer Center
2279 45th Street
Sacramento, CA 95817
Phone: 916-734-5959
Additional Numbers
Physician Referrals
Philosophy of Care
This is an exciting time to be in the field of stem cell transplant, as we are constantly expanding the diseases for which we can offer transplant, sometimes using modalities which are less toxic to the patient, such as reduced intensity preparative regimens, engineering of the patients' own cells, and early targeted treatment for many transplant related complications, as well as expanded donor options for patients who in the past would not have been able to receive a potentially curative transplant.
In terms of how I approach transplant, I see the family as part of the team, with the common goal for all of curing the patient, with as little trauma around the experience as possible. I like to take time to not just inform but educate the patient and family so that they understand as fully as possible every step of the process. While the medical team knows diseases, the family knows their child, and so their input is important to optimizing care. I also think communication and transparency are so important. I never want a patient or family to feel like they're "in the dark." Transplant is like a voyage we take together.
Clinical Interests
Dr. Madden is a pediatric hematologist and oncologist offering care for children and young adults with various malignant and non-malignant hematological disorders. She has special interest and expertise in stem cell transplant ("bone marrow transplant") and cellular therapies. While she is interested in all transplantable diagnoses, she has particular interest in curative treatment for hemoglobinopathies, particularly sickle cell disease and thalassemia, as well as alternative donor transplant for high risk leukemias.
Research/Academic Interests
Dr. Madden has interest in optimizing curative options for hemoglobinopathies, including gene editing, (CRISPR) technologies. She is also interested in optimizing the graft vs. malignancy effects in allogeneic transplant for leukemias and lymphomas. Further, she works on novel strategies for treating major transplant related complications, such as Graft vs. Host Disease (GVHD), and infection prevention.
Division
Pediatric Hematology/Oncology
Center/Program Affiliation
UC Davis Children's Hospital
UC Davis Comprehensive Cancer Center
Undergraduate School
B.S., Chemistry, Fordham University, New York 1988
Medical School
M.D., Michigan State, MI 2001
Other School
M.S., Chemical Physics, University of Notre Dame, IN 1992
Internship
Pediatrics, University of Iowa Hospitals and Clinics, IA 2001-2002
Residency
Pediatrics, University of Iowa Hospitals and Clinics, IA 2002-2004
Fellowship
Pediatrics/Hematology-Oncology, University of Michigan School of Medicine, MI 2004-2007
University of Michigan Medical School, Helen L. Kay Pediatric Cancer Research Award, 2009
University of Michigan Medical School, Nancy Newton Loeb Pediatric Cancer Research Award, 2008
University of Michigan Medical School, Faculty Award for Basic Science Research, University of Michigan, Department of Pediatrics, 2007
University of Michigan Medical School, NIH Molecular Biology Research Fellowship award, 2005
Michigan State University College of Human Medicine, Rita Hopkinson Memorial Scholarship for academic excellence and volunteer work with children, 2001
Michigan State University College of Human Medicine, Arthur Foley Memorial Scholarship for academic excellence, mentorship and anticipated career in research, 2009
Cuvlier G, Logan BR, Prockop S, et. al., Outcomes following treatment for adenosine deaminase deficient severe combined immunodeficiency: a report from the PIDTC, Blood, June 7, 2022 (online ahead of print)
Rattani, N., Matheny, C, Eckrich, MJ, Madden, LM, Quigg, TC, Parvovirus B19-associated graft failure after allogeneic hematopoietic stem cell transplant, Cancer Rep, 5(1), January 2022
Madden,L.M., Hayashi, R.J., Chan, K.W., Pulsipher, M.A., Douglas, D., Hale, G.A., Shaudhury, S. Haut P., Kasow, K.A., Gilman, A.L., Murray, L.M., Shenoy, S. (2016). Long-term follow-up after reduced-intensity Conditioning and stem cell transplantation for childhood nonmalignant Disorders. Bio Blood and Marrow Transplant, 22 (8) 1467-72, Pubmed 27164064
Mull, J.L.,Madden, L.M, Bayless, S.J. (2016). Myelodysplastic syndrome Occurring in a patient with Gorlin Syndrom. Pediatric Dermatology, 33 (4) PubMed 2724174
Madden, L. M., Ngwube, A. I., Shenoy, S., Druley, T. E., Hayashi, R. J. (2014) Late Toxicity of a Novel Allogeneic Stem Cell Transplant Using Single Fraction Total Body Irradiation for Hematologic Malignancies in Children. J Pediat Hematol Oncol PubMed: 25333837
Rosebeck, S. and Madden, L., Jin, X., Gu, S., Apel, I. J., Appert, A., Hamoudi, R. A., Noels, H., Sagaert, X., Van Loo, P., Baens, M., Du, M. Q., Lucas, P. C., McAllister-Lucas, L. M. (2011). Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science, 331 (6016), 468-72. PMCID: PMC3124150 PubMed: 21273489.
Marsh, R. A., Madden, L., Kitchen, B. J., Mody, R., McClimon, B., Jordan, M. B., Bleesing, J. J., Zhang, K., Filipovich, A. H. (2010). XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease. Blood, 116 (7), 1079-82. PMCID: PMC2938130 PubMed: 20489057
Marsh, R. A., Villanueva, J., Zhang, K., Snow, A. L., Su, H. C., Madden, L., Mody, R., Kitchen, B., Marmer, D., Jordan, M. B., Risma, K. A., Filipovich, A. H., Bleesing, J. J. (2009). A rapid flow cytometric screening test for X- linked lymphoproliferative disease due to XIAP deficiency. Cytometry B Clin Cytom, 76 (5), 334-44. PMCID: PMC2728163 PubMed: 19288545.
Mavis, B. E., Ogle, K. S., Lovell, K. L., Madden, L. M. (2002). Medical students as standardized patients to assess interviewing skills for pain evaluation. Med Educ,36 (2), 135-40 PubMed: 11869440.