UC Davis Health
School of Medicine

Daniah Beleford, M.D., Ph.D. | Physiology and Membrane Biology | UC Davis School of Medicine

Daniah Beleford, M.D., Ph.D.

Research Interests

Beleford's research program within the Department of Physiology and Membrane Biology and Department of Pediatrics studies molecular genetic causes of vascular anomalies - disorders of arterial, venous, and lymphatic formation. Beleford's group is interested in genetic modifiers of rare vascular conditions such as Hereditary Hemorrhagic Telangiectasia and in clarifying molecular signals and interactions that cause vascular disease. The lab utilizes mouse disease modeling and basic molecular biology techniques.

Graduate Group Affiliations

Published work can be found in My Bibliography »

  1. Dragic, T, Trkola, A, Thompson, DA, Cormier, E, Kajumo, F, Maxwell, E, Lin, S, Ying, W, Smith, S, Sakmar, P, Moore, JP (2000). "A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5". PNAS May 9; 97(10): 5639-5644. PMID: 10779565.
  2. Cormier, EG, Persuh, M, Thompson, DA, Lin, SW, Sakmar, TP, Olson, WC, Dragic, T (2000). "Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120". PNAS May 23; 97(11): 5762-5767. PMID: 10823934.
  3. Kajumo, F, Thompson, DA, Guo, Y, Dragic, T (2000). "Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4". Virology June 5; 271(2): 240-247. PMID: 10860877.
  4. Nagashima, KA, Thompson, DA, Rosenfield, SI, Maddon, PJ, Dragic, T, Olson, WC (2001). "Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion". Journal of Infectious Diseases April 1; 183(7): 1121-1125. PMD: 11237840.
  5. Thompson, DA, Cormier, EG, Dragic, T (2002). "CCR5 and CXCR4 Usage by Non Clade B Human Immunodeficiency Virus Type 1 Primary Isolates". Journal of Virology March; 76(6): 3059-3064. PMID: 11861874.
  6. Vanegas, M, Llano, M, Delgado, S, Thompson, D, Peretz, M, Poeschla, E (2005). "Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering". Journal of Cell Science April 15;118(Pt8): 1733-1743. PMID: 15797927.
  7. Llano, M, Vanegas, M, Hutchins, N, Thompson, D, Delgado, S, Poeschla, E (2006). "Identification and Characterization of the Chromatin-binding Domains of the HIV-1 Integrase Interactor LEDGF/p75". Journal of Molecular Biology July 21 360(4): 760-773. PMID: 16793062.
  8. Chien, J, Narita, K, Rattan, R, Giri, S, Shridhar, R, Staub, J, Beleford, D, Lai, L, Roberts, L, Molina, J, Kaufmann, SH, Predergast, GC and Shridhar, V (2008). "A Role for Candidate Tumor Suppressor Gene TCEAL7 in the Regulation of c-Myc Activity, Cyclin D1 Levels and Cellular Transformation". Oncogene September 22: 1-12. PMID: 18806825.
  9. Beleford, D, Liu, Z, Rattan, R, Quagliuolo, L, Boccellino, M, Baldi, A, Maguire, J, Staub, J, Molina, J, Shridhar, V (2010). "Methylation-induced gene silencing of HtrA3 in smoking-related lung cancer". Clinical Cancer Research January 15;16(2):398-409. PMID: 20068077.
  10. Beleford, D, Rattan, R, Chien, J, Shridhar, V (2010). "High-temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines". Journal of Biological Chemistry April 16;285(16):12011-12027. PMID: 20154083.
  11. Khurana, A, Beleford, D, He, X, Chien, J, and Shridhar, V (2013). "The role of heparin sulfatases in ovarian and breast cancer". American Journal of Cancer Research 3(1):34-45. PMID: 23359864.
  12. Beleford, D and Shridhar, V. (2013). "HtrA3 Peptidase. In Handbook of Proteolytic Enzymes (Vol. 3, pp. 2584-2590)". Elsevier Ltd.  https://doi.org/10.1016/B978-0-12-382219-2.00572-X
  13. Chan, AK, Han SJ, Choy W, Beleford, D, Aghi MK, Berger MS, Shieh JT, Bollen AW, Perry A, Phillips JJ, Butowski N, Solomon DA. "Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history" (2017). Clin Neuropathol. Sep/Oct;36(5):213-221. PMID: 28699883.
  14. Kumar A, Zastrow DB, Kravets EJ, Beleford D, Ruzhnikov MRZ, Grove ME, Dries AM, Kohler JN, Waggott DM, Yang Y, Huang Y; Undiagnosed Diseases Network, Mackenzie KM, Eng CM, Fisher PG, Ashley EA, Teng JM, Stevenson DA, Shieh JT, Wheeler MT, Bernstein JA. "Extracutaneous Manifestations in Phacomatosis Cesioflammea and Cesiomarmorata: Case Series and Literature Review" (2019) American Journal of Medical Genetics A, Jun;179(6):966-977. PMID: 30920161.
  15. Beleford, DT, Diab, M, Qubty, WF, Malloy, MJ, Long, RK, Shieh, JT. "Schimke Immunoosseous Dysplasia and Management Considerations for Vascular Risks" (2019). American Journal of Medical Genetics A, Jul;179(7):1246-1252. PMID: 31039288.
  16. Ha, TK, Mardy, AH, Beleford, D, Spanier, A, Wayman, BV, Penon-Portman, M, Wiita, AP, Shieh, JT. "Characterization of a Novel X-Linked Copy Number Variation Associated with Overgrowth" (2019) American Journal of Medical Genetics C Semin Med Genet, Dec;181(4):644-64. PMID: 31762227.
  17. Mendelsohn*, B, Beleford*, D, Abu-El-Haija, A, Alsaleh, N, Rahbeeni, Z, Martin, PM, Rego, S,Huang, A, Capodanno, G, Shieh, JT, Van Ziffle, J, Risch, N, Alkuraya, F, Slavotinek, A. *Authors contributed equally. (2020) "A novel truncating variant in ring finger protein A (RNF113A) confirms the association of this gene with X-linked trichothiodystrophy". American Journal of Medical Genetics A, Mar;182(3):513-520. PMID: 31880405.
  18. Beleford, DT, Van Ziffle, J, Hodoglugil, U, Slavotinek, A (2020). "A missense variant, p.(Ile269Asn), in MC4R as a secondary finding in a child with BCL11A-related intellectual disability". European Journal of Medical Genetics Jun 10; 103969. PMID: 32534219
  19. Peron al. "BCL11A Intellectual Development Disorder: Defining the Clinical Spectrum and Genotype-Phenotype Correlations". medRxiv (2021) 09.06.21262776.
  20. Shieh*, JT, Penon-Portmann*, M, Wong*, KHY, Levy-Sakin, M, Verghese, M, Slavotinek, A, Gallagher, R, Mendelsohn, B, Tenney, J,Beleford, D, Perry, H, Chow, SK, Sharo, A, Qi, Z, Yu, J, Klein, O, Martin, P, Kwok, PY, Boffelli, D. *Authors contributed equally (2021). "Application of Full Genome Analysis to Diagnose Rare Monogenic Disorders". NPJ Genomic Medicine. 2021 Sep 23;6(1):77.
  • M.D., Mayo Clinic College of Medicine Medical Scientist Training Program (MSTP)
  • Ph.D., Mayo Clinic College of Medicine Medical Scientist Training Program (MSTP), Biochemistry and Molecular Biology
  • Residency, Medical Genetics and Genomics, UC San Francisco School of Medicine, San Francisco, CA 2016-2018
  • Fellowship, Medical Genetics and Genomics, UC San Francisco School of Medicine, San Francisco, CA 2018-2019
  • NIH T32 Postdoctoral Research Fellowship/Lung Biology, UC San Francisco School of Medicine, San Francisco, CA 2018-2019
  • Post-Doctoral Research Fellowship/Vascular Biology, UC San Francisco School of Medicine, San Francisco, CA 2020
  • UC President's Postdoctoral Research Fellowship/Vascular Biology, UC San Francisco School of Medicine, San Francisco, CA 2021-2023